Аутори:
1. Nevena Jokić, Медицински факултет Бања Лука , Republic of Srpska, Bosnia and Herzegovina
2. Branka Rodić-Grabovac, Технолошки факултет Универзитета у Бањој Луци, Republic of Srpska, Bosnia and Herzegovina
3. Ljiljana Topalić-Trivunović, Технолошки факултет Универзитета у Бањој Луци, Republic of Srpska, Bosnia and Herzegovina

Апстракт:
Plants of the genus Achillea (family Compositae) have many bioactive ingredients, among which flavonoid compounds are the most important. Flavonoids are secondary metabolites that are widely distributed in the plant world and have various functions in the metabolism of the plants. This paper presents research results of the most important flavonoid compounds presented in Achillea species, including apigenin, luteolin, quercetin and their glucosides, as the most common compounds. Among flavonoid heterosides are found monoglycosides (mainly O-glucosides, C-glucosides and O-glucuronides) and diglycosides (O-diglucosides, C-diglucosides and O-rutinosides). Experiments have shown that flavonoids found in plants of this genus have a wide range of biological activities. Research conducted on guinea-pig terminal ilea showed spasmolytic activity of apigenin, luteolin and quercetin. It has been shown that luteolin and apigenin have estrogenic activity, and it is also important antidiabetic activity of luteolin as a result of inhibition of the enzyme α-glucosidase. On various cancer cell lines is shown that casticin and centaureidin, also important flavonoids of the genus Achillea, have anti-tumor activity, and the experiment conducted in rats showed antihypertensive activity of flavonoid artemetin. It is known that flavonoids have antioxidant activity, and this is also confirmed in Achillea species.

Кључне речи:
Achillea,flavonoid compounds,biological activity

Тематска област:
Теоријска и примијењена хемија

Датум пријаве сажетка:
23.05.2016.

Конференцијa:
XI Savjetovanje hemičara, tehnologa i ekologa Republike Srpske

Финални рад Рад за рецензију Сажетак рада